CYP21A2 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP21A2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1754.55	226 / 226	83%	5.12	339 / 406
adrenal gland	100%	109739.52	258 / 258	53%	324.21	121 / 230
kidney	98%	306.98	87 / 89	46%	1.32	410 / 901
breast	80%	92.35	365 / 459	59%	2.97	665 / 1118
thymus	97%	163.14	634 / 653	40%	1.28	243 / 605
ovary	100%	257.68	180 / 180	28%	0.86	122 / 430
brain	79%	72.57	2087 / 2642	47%	1.37	330 / 705
uterus	94%	115.48	160 / 170	9%	0.29	40 / 459
spleen	99%	329.62	239 / 241	0%	0	0 / 0
prostate	90%	124.04	221 / 245	8%	0.11	41 / 502
bladder	90%	124.62	19 / 21	3%	0.05	13 / 504
intestine	85%	103.47	822 / 966	2%	0.02	8 / 527
lung	74%	40.54	429 / 578	7%	0.35	78 / 1155
esophagus	75%	86.05	1089 / 1445	3%	0.10	6 / 183
adipose	75%	67.34	897 / 1204	0%	0	0 / 0
blood vessel	62%	41.96	833 / 1335	0%	0	0 / 0
stomach	57%	31.06	206 / 359	1%	0.01	2 / 286
heart	56%	71.12	478 / 861	0%	0	0 / 0
pancreas	44%	23.11	143 / 328	6%	3.00	11 / 178
skin	36%	18.79	660 / 1809	1%	2.06	6 / 472
peripheral blood	20%	11.61	190 / 929	0%	0	0 / 0
muscle	9%	4.27	70 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.01	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006704	Biological process	glucocorticoid biosynthetic process
GO_0006705	Biological process	mineralocorticoid biosynthetic process
GO_0008202	Biological process	steroid metabolic process
GO_0016125	Biological process	sterol metabolic process
GO_0006694	Biological process	steroid biosynthetic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0106309	Molecular function	progesterone 21-hydroxylase activity
GO_0005506	Molecular function	iron ion binding
GO_0103069	Molecular function	17-hydroxyprogesterone 21-hydroxylase activity
GO_0004509	Molecular function	steroid 21-monooxygenase activity
GO_0008395	Molecular function	steroid hydroxylase activity
GO_0020037	Molecular function	heme binding
GO_0005496	Molecular function	steroid binding

IV. Literature review

[source]

Gene name	CYP21A2
Protein name	21-hydroxylase (EC 1.14.14.16) CYP21A2 protein Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) 21-hydroxylase Mutant 21 hydroxylase (EC 1.14.99.10) Cytochrome P-450 c21 hydroxylase enzyme (EC 1.14.99.10) Steroid 21-hydroxylase (EC 1.14.99.10) Cytochrome P450 family 21 subfamily A member 2 Steroid 21 hydroxylase Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B) Steroid 21-hydroxylase Steroid 21-monooxygenase (EC 1.14.99.10) Truncated cytochrome P-450 c21 hydroxylase enzyme 21-hydroxylase (EC 1.14.99.10)
Synonyms	CYP21B CYP21
Description	FUNCTION: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .
Accessions	E7EN87 C7DTY4 ENST00000434026.2 [P08686-2] C7DU17 ENST00000448478.6 [P08686-1] B2D081 C7DTW5 E7EVC0 B2YHV7 A0A4P2UU84 ENST00000471671.4 Q1EM52 A0A4P2V2R5 Q1H8Y2 A0A023J7R6 C7DU04 ENST00000383321.4 [P08686-2] ENST00000452708.2 C7DTW8 Q1H8Y3 C7DU10 C7DTV1 ENST00000448314.6 Q1H8Y4 A0A1L6Z3L5 Q1EM51 E9M5C7 C7DTU9 A0A1P8SW53 K9LHU7 B6VE01 B8YJC6 C7DTY1 C7DU00 A0A4P2UTF4 Q08AG9 U5YU50 B2YHV6 C7DTW2 C7DTW4 K9LII7 E9M5C8 A0A1P8SW43 V5WC48 A9UF27 Q1H8Y5 K9LHV3 K9LHV1 ENST00000448877.2 C7DTX2 E9M5C9 A0A1L6Z3K9 ENST00000456152.6 [P08686-1] A0A0G2JJF2 ENST00000435122.3 [P08686-2] A9UF28 P08686 K9LHU1 A8W368 A6ZI22 A0A1P8SW42 C7DTX7 E7ERT7 ENST00000644719.2 [P08686-1] C7DU02 A1A5B1 E9M5D0 A0A2U7NZY9 C7DTV0 E9M5D1 F8WBR4 C7DTV6 C6K7H0 K9LII5 K9LIR4 C7DTY5 C6K7H1 C7DTZ2 ENST00000452386.2 [P08686-2] A5HSJ6 ENST00000478281.5 C7DTX8 ENST00000383322.8 [P08686-1] Q2UVX6 C7DTW1 Q2UVX5 A0A1U9IMX4 Q1EM53 Q16742 ENST00000466779.5 A0A1P8SW33 C7DTX9 ENST00000469053.5 ENST00000436607.6

CYP21A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review