CYP11B2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP11B2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP11B2 at tissue level.

III. Associated gene sets

GO_0035865Biological processcellular response to potassium ion
GO_0003091Biological processrenal water homeostasis
GO_0034650Biological processcortisol metabolic process
GO_0055078Biological processsodium ion homeostasis
GO_0008203Biological processcholesterol metabolic process
GO_0006704Biological processglucocorticoid biosynthetic process
GO_0032870Biological processcellular response to hormone stimulus
GO_0016125Biological processsterol metabolic process
GO_0055075Biological processpotassium ion homeostasis
GO_0006700Biological processC21-steroid hormone biosynthetic process
GO_0002017Biological processregulation of blood volume by renal aldosterone
GO_0034651Biological processcortisol biosynthetic process
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0006705Biological processmineralocorticoid biosynthetic process
GO_0032342Biological processaldosterone biosynthetic process
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0047783Molecular functioncorticosterone 18-monooxygenase activity
GO_0004507Molecular functionsteroid 11-beta-monooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0008395Molecular functionsteroid hydroxylase activity

IV. Literature review

[source]
Gene nameCYP11B2
Protein nameSteroid 18-hydroxylase
Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of heart failure . Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that would not leave the enzyme active site during the consecutive hydroxylation reactions), ending with the formation of aldosterone . Can also produce 18-hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) . Could also be involved in the androgen metabolic pathway (Probable). .

AccessionsQ16316
ENST00000323110.2
Q16315
P19099