CYP11B1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP11B1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP11B1 at tissue level.

III. Associated gene sets

GO_0035865Biological processcellular response to potassium ion
GO_0034650Biological processcortisol metabolic process
GO_0008217Biological processregulation of blood pressure
GO_0008203Biological processcholesterol metabolic process
GO_0006704Biological processglucocorticoid biosynthetic process
GO_0032870Biological processcellular response to hormone stimulus
GO_0016125Biological processsterol metabolic process
GO_0006700Biological processC21-steroid hormone biosynthetic process
GO_0006955Biological processimmune response
GO_0034651Biological processcortisol biosynthetic process
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0032342Biological processaldosterone biosynthetic process
GO_0042593Biological processglucose homeostasis
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0047783Molecular functioncorticosterone 18-monooxygenase activity
GO_0004507Molecular functionsteroid 11-beta-monooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding

IV. Literature review

[source]
Gene nameCYP11B1
Protein nameMitochondrial 11beta-hydroxylase
Truncated steroid 11beta-hydroxylase
Steroid 11-beta-hydroxylase (EC 1.14.15.4)
CYP11B1 protein (Cytochrome P450 family 11 subfamily B member 1)
Truncated mitochondrial cytochrome P450 11B1
Cytochrome P450 11B1, mitochondrial (CYP11B1) (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B1) (EC 1.14.15.4)
Cytochrome P450 family 11 subfamily B member 1
SynonymsS11BH
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids . Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19 (By similarity). Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) . Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone . Could also be involved in the androgen metabolic pathway (Probable). .

AccessionsP15538
ENST00000519285.5
D2KC07
Q8TE40
Q8TE41
ENST00000377675.3
A9UF29
Q8TE38
ENST00000292427.10 [P15538-1]
Q4VAR0
Q8TE39
ENST00000517471.5 [P15538-2]
H0YBR4