CRPPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008299Biological processisoprenoid biosynthetic process
GO_0007411Biological processaxon guidance
GO_0035269Biological processprotein O-linked mannosylation
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0070567Molecular functioncytidylyltransferase activity
GO_0047349Molecular functionD-ribitol-5-phosphate cytidylyltransferase activity

IV. Literature review

[source]
Gene nameCRPPA
Protein nameD-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (Isoprenoid synthase domain-containing protein) (hISPD)
D-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (Isoprenoid synthase domain-containing protein)
SynonymsISPD
DescriptionFUNCTION: Cytidylyltransferase required for protein O-linked mannosylation . Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate . CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity . Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively . Not Involved in dolichol production . .

AccessionsENST00000676325.1
A4D126
A0A6Q8PG39
A0A6Q8PF75
ENST00000399310.3 [A4D126-2]
A0A6Q8PHI3
ENST00000675257.1
ENST00000407010.7 [A4D126-1]
ENST00000674759.1