I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 30% ± 15% | |
| erythrocyte | 4 studies | 49% ± 17% | |
| glutamatergic neuron | 3 studies | 34% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 30% ± 15% | |
| erythrocyte | 4 studies | 49% ± 17% | |
| glutamatergic neuron | 3 studies | 34% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 29% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 100% | 1361.16 | 170 / 170 | 100% | 31.95 | 459 / 459 |
| esophagus | 100% | 1312.98 | 1444 / 1445 | 100% | 30.64 | 183 / 183 |
| brain | 100% | 1513.03 | 2640 / 2642 | 100% | 18.94 | 705 / 705 |
| intestine | 100% | 1182.23 | 966 / 966 | 100% | 27.31 | 526 / 527 |
| bladder | 100% | 1126.19 | 21 / 21 | 100% | 25.00 | 503 / 504 |
| ovary | 100% | 1163.48 | 180 / 180 | 100% | 17.23 | 429 / 430 |
| stomach | 99% | 909.91 | 357 / 359 | 100% | 24.62 | 286 / 286 |
| lung | 99% | 994.31 | 573 / 578 | 100% | 27.51 | 1154 / 1155 |
| prostate | 100% | 1039.85 | 245 / 245 | 99% | 14.75 | 497 / 502 |
| liver | 100% | 2364.02 | 226 / 226 | 98% | 15.25 | 399 / 406 |
| skin | 100% | 1423.21 | 1808 / 1809 | 98% | 35.71 | 464 / 472 |
| breast | 100% | 1045.01 | 458 / 459 | 98% | 14.71 | 1100 / 1118 |
| thymus | 100% | 992.15 | 652 / 653 | 98% | 13.39 | 594 / 605 |
| pancreas | 98% | 601.76 | 322 / 328 | 99% | 17.32 | 176 / 178 |
| kidney | 98% | 680.53 | 87 / 89 | 99% | 14.53 | 888 / 901 |
| adrenal gland | 100% | 1257.98 | 258 / 258 | 93% | 12.07 | 214 / 230 |
| adipose | 100% | 1054.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 20.64 | 29 / 29 |
| spleen | 100% | 1359.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 37.18 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.53 | 1 / 1 |
| blood vessel | 100% | 1068.86 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 691.53 | 844 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 595.15 | 786 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 2153.51 | 755 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 79% | 8.01 | 63 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006782 | Biological process | protoporphyrinogen IX biosynthetic process |
| GO_0006783 | Biological process | heme biosynthetic process |
| GO_0006784 | Biological process | heme A biosynthetic process |
| GO_0006785 | Biological process | heme B biosynthetic process |
| GO_0048034 | Biological process | heme O biosynthetic process |
| GO_0005758 | Cellular component | mitochondrial intermembrane space |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004109 | Molecular function | coproporphyrinogen oxidase activity |
| GO_0005212 | Molecular function | structural constituent of eye lens |
| Gene name | CPOX |
| Protein name | Coproporphyrinogen oxidase Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) |
| Synonyms | CPO CPX |
| Description | FUNCTION: Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway. . |
| Accessions | P36551 D6RER6 ENST00000513674.1 ENST00000647941.2 [P36551-1] |
