CPLX3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CPLX3 at tissue level.

III. Associated gene sets

GO_0030073Biological processinsulin secretion
GO_0007601Biological processvisual perception
GO_0031630Biological processregulation of synaptic vesicle fusion to presynaptic active zone membrane
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0046928Biological processregulation of neurotransmitter secretion
GO_0043195Cellular componentterminal bouton
GO_0048787Cellular componentpresynaptic active zone membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0098684Cellular componentphotoreceptor ribbon synapse
GO_0005829Cellular componentcytosol
GO_0031201Cellular componentSNARE complex
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0000149Molecular functionSNARE binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameCPLX3
Protein nameComplexin-3 (Complexin III) (CPX III)
SynonymsNbla11589
DescriptionFUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). .

AccessionsQ8WVH0
ENST00000395018.6