COX7B2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of COX7B2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of COX7B2 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0006123Biological processmitochondrial electron transport, cytochrome c to oxygen
GO_0045277Cellular componentrespiratory chain complex IV
GO_0005746Cellular componentmitochondrial respirasome
GO_0005739Cellular componentmitochondrion

IV. Literature review

[source]
Gene nameCOX7B2
Protein nameCytochrome c oxidase subunit 7B2, mitochondrial (Cytochrome c oxidase polypeptide VIIb2)
Cytochrome c oxidase subunit 7B2
Synonyms
DescriptionFUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .

AccessionsD6R9N1
ENST00000505102.1
Q8TF08
ENST00000543208.5
A0A0C4DGG2
ENST00000355591.8
ENST00000396533.5