I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 5 studies | 36% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 5 studies | 36% ± 9% |
Insufficient scRNA-seq data for expression of COX6A2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| muscle | 100% | 21362.19 | 803 / 803 | 0% | 0 | 0 / 0 |
| heart | 100% | 14759.49 | 860 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 19.57 | 73 / 80 |
| liver | 0% | 1.50 | 1 / 226 | 54% | 3.57 | 218 / 406 |
| kidney | 0% | 0 | 0 / 89 | 39% | 0.88 | 354 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 36% | 3.51 | 16 / 45 |
| adrenal gland | 0% | 0 | 0 / 258 | 34% | 1.37 | 78 / 230 |
| uterus | 0% | 0 | 0 / 170 | 29% | 5.19 | 134 / 459 |
| ovary | 0% | 0 | 0 / 180 | 29% | 0.74 | 123 / 430 |
| skin | 0% | 6.49 | 3 / 1809 | 18% | 0.81 | 83 / 472 |
| prostate | 6% | 115.28 | 15 / 245 | 11% | 4.27 | 55 / 502 |
| brain | 0% | 0.13 | 1 / 2642 | 15% | 0.28 | 106 / 705 |
| breast | 1% | 12.95 | 6 / 459 | 10% | 0.32 | 117 / 1118 |
| lung | 0% | 14.42 | 1 / 578 | 5% | 0.15 | 57 / 1155 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.03 | 1 / 29 |
| stomach | 0% | 0 | 0 / 359 | 3% | 0.07 | 8 / 286 |
| peripheral blood | 2% | 39.31 | 22 / 929 | 0% | 0 | 0 / 0 |
| esophagus | 1% | 5.01 | 10 / 1445 | 2% | 0.03 | 3 / 183 |
| thymus | 1% | 8.80 | 6 / 653 | 1% | 0.13 | 8 / 605 |
| blood vessel | 2% | 53.09 | 25 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 2% | 0.02 | 3 / 178 |
| intestine | 0% | 0 | 0 / 966 | 2% | 0.07 | 8 / 527 |
| bladder | 0% | 0 | 0 / 21 | 1% | 0.04 | 7 / 504 |
| adipose | 1% | 3.93 | 8 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006091 | Biological process | generation of precursor metabolites and energy |
| GO_0006123 | Biological process | mitochondrial electron transport, cytochrome c to oxygen |
| GO_0005751 | Cellular component | mitochondrial respiratory chain complex IV |
| GO_0016491 | Molecular function | oxidoreductase activity |
| GO_0030234 | Molecular function | enzyme regulator activity |
| Gene name | COX6A2 |
| Protein name | Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (Cytochrome c oxidase subunit VIA-muscle) (COX VIa-M) Cytochrome c oxidase subunit (Cytochrome c oxidase polypeptide VIa) |
| Synonyms | COX6AH COX6A |
| Description | FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV . . |
| Accessions | H6SG13 ENST00000287490.5 Q02221 |
