COX4I2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of COX4I2 at tissue level.

III. Associated gene sets

GO_0006123Biological processmitochondrial electron transport, cytochrome c to oxygen
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0045333Biological processcellular respiration
GO_1902600Biological processproton transmembrane transport
GO_0005751Cellular componentmitochondrial respiratory chain complex IV
GO_0004129Molecular functioncytochrome-c oxidase activity

IV. Literature review

[source]
Gene nameCOX4I2
Protein nameCytochrome c oxidase subunit 4
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)
SynonymsCOX4L2
hCG_37391
DescriptionFUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .

FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. .

AccessionsENST00000376075.4
H6SG14
Q96KJ9