COQ2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of COQ2 at tissue level.

III. Associated gene sets

GO_0006071Biological processglycerol metabolic process
GO_0008299Biological processisoprenoid biosynthetic process
GO_0006744Biological processubiquinone biosynthetic process
GO_0005743Cellular componentmitochondrial inner membrane
GO_0047293Molecular function4-hydroxybenzoate nonaprenyltransferase activity
GO_0004659Molecular functionprenyltransferase activity
GO_0008412Molecular function4-hydroxybenzoate octaprenyltransferase activity
GO_0002083Molecular function4-hydroxybenzoate decaprenyltransferase activity

IV. Literature review

[source]
Gene nameCOQ2
Protein name4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (4-hydroxybenzoate decaprenyltransferase) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)
Coenzyme Q2, polyprenyltransferase
4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (4-hydroxybenzoate decaprenyltransferase) (COQ2 homolog) (hCOQ2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)
SynonymsCL640
DescriptionFUNCTION: Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis . Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate) . The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls (decaprenyl) producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 . However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 . Plays a central role in the biosynthesis of CoQ10 . CoQ10 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes . CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway . Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity). .

FUNCTION: Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital molecules that transport electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner. .

AccessionsENST00000311469.9 [Q96H96-4]
ENST00000311461.7
ENST00000311461.7 [Q96H96-3]
E2QRG7
ENST00000503391.5
ENST00000503915.5
ENST00000647002.2 [Q96H96-1]
H0YAI0
E7EPM7
Q96H96