CNGA4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CNGA4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	68.49	2626 / 2642	46%	0.83	321 / 705
ovary	94%	37.93	170 / 180	17%	0.63	72 / 430
lung	91%	107.95	527 / 578	19%	0.77	221 / 1155
uterus	97%	52.99	165 / 170	6%	0.33	29 / 459
bladder	100%	23.05	21 / 21	3%	0.13	15 / 504
spleen	95%	32.15	229 / 241	0%	0	0 / 0
kidney	84%	20.76	75 / 89	10%	0.19	94 / 901
prostate	90%	24.32	221 / 245	4%	0.12	22 / 502
peripheral blood	91%	51.66	843 / 929	0%	0	0 / 0
thymus	86%	20.64	562 / 653	4%	0.06	25 / 605
pancreas	84%	19.10	274 / 328	6%	0.12	10 / 178
breast	78%	19.37	360 / 459	10%	0.21	117 / 1118
intestine	83%	19.96	806 / 966	4%	0.06	19 / 527
stomach	80%	15.60	288 / 359	3%	0.04	8 / 286
adrenal gland	82%	18.45	211 / 258	0%	0.00	1 / 230
blood vessel	79%	15.87	1061 / 1335	0%	0	0 / 0
esophagus	70%	13.88	1007 / 1445	4%	0.04	7 / 183
adipose	70%	13.89	847 / 1204	0%	0	0 / 0
skin	64%	11.94	1151 / 1809	4%	0.08	19 / 472
liver	55%	8.89	125 / 226	1%	0.02	5 / 406
heart	32%	4.47	274 / 861	0%	0	0 / 0
muscle	9%	1.05	71 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006813	Biological process	potassium ion transport
GO_0007608	Biological process	sensory perception of smell
GO_0006814	Biological process	sodium ion transport
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_0006816	Biological process	calcium ion transport
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0060170	Cellular component	ciliary membrane
GO_0098804	Cellular component	non-motile cilium membrane
GO_0030660	Cellular component	Golgi-associated vesicle membrane
GO_0017071	Cellular component	intracellular cyclic nucleotide activated cation channel complex
GO_0005886	Cellular component	plasma membrane
GO_0044877	Molecular function	protein-containing complex binding
GO_0005222	Molecular function	intracellularly cAMP-activated cation channel activity
GO_0005223	Molecular function	intracellularly cGMP-activated cation channel activity
GO_0030552	Molecular function	cAMP binding
GO_0005262	Molecular function	calcium channel activity
GO_0030553	Molecular function	cGMP binding

Gene name	CNGA4
Protein name	Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4) Cyclic nucleotide gated channel subunit alpha 4 (cDNA FLJ51400, highly similar to Cyclic nucleotide-gated ol factory channel subunit OCNC2)
Synonyms
Description	FUNCTION: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). .
Accessions	Q8IV77 ENST00000533426.5 B4DYQ8 ENST00000379936.3 [Q8IV77-1]

CNGA4 report