CMPK2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CMPK2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CMPK2 at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0046940Biological processnucleoside monophosphate phosphorylation
GO_0006227Biological processdUDP biosynthetic process
GO_0006233Biological processdTDP biosynthetic process
GO_0006235Biological processdTTP biosynthetic process
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0004127Molecular function(d)CMP kinase activity
GO_0033862Molecular functionUMP kinase activity
GO_0036430Molecular functionCMP kinase activity
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_0036431Molecular functiondCMP kinase activity
GO_0004798Molecular functionthymidylate kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCMPK2
Protein nameUMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6)
Mitochondrial cytidine monophosphate (UMP-CMP) kinase 2
Synonyms
DescriptionFUNCTION: Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways . Restricts the replication of multiple viruses including flaviviruses or coronaviruses . Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities . Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity . Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (By similarity). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (By similarity). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (By similarity). .

AccessionsENST00000256722.10 [Q5EBM0-1]
Q5EBM0
ENST00000404168.1 [Q5EBM0-4]
I1Z9C7
ENST00000458098.5 [Q5EBM0-3]