Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 14 studies | 40% ± 18% | |
endothelial cell | 9 studies | 22% ± 9% | |
macrophage | 7 studies | 21% ± 6% | |
microglial cell | 6 studies | 28% ± 13% | |
epithelial cell | 6 studies | 23% ± 12% | |
GABAergic neuron | 4 studies | 36% ± 12% | |
glutamatergic neuron | 4 studies | 45% ± 11% | |
cardiac muscle cell | 3 studies | 17% ± 2% | |
hepatocyte | 3 studies | 58% ± 19% | |
retinal pigment epithelial cell | 3 studies | 27% ± 10% | |
lymphocyte | 3 studies | 23% ± 5% | |
basal cell | 3 studies | 20% ± 3% | |
transit amplifying cell | 3 studies | 22% ± 8% | |
adipocyte | 3 studies | 18% ± 2% | |
interneuron | 3 studies | 36% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 30% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 2037.37 | 89 / 89 | 99% | 7.19 | 893 / 901 |
liver | 100% | 1818.31 | 226 / 226 | 98% | 6.96 | 399 / 406 |
thymus | 100% | 691.74 | 653 / 653 | 96% | 2.55 | 583 / 605 |
intestine | 100% | 743.38 | 966 / 966 | 95% | 3.39 | 499 / 527 |
brain | 100% | 530.35 | 2631 / 2642 | 95% | 2.23 | 668 / 705 |
prostate | 100% | 465.65 | 245 / 245 | 93% | 2.08 | 468 / 502 |
stomach | 100% | 351.77 | 359 / 359 | 92% | 3.25 | 262 / 286 |
ovary | 98% | 310.13 | 176 / 180 | 91% | 2.61 | 390 / 430 |
pancreas | 99% | 333.63 | 326 / 328 | 85% | 1.73 | 152 / 178 |
breast | 100% | 456.29 | 459 / 459 | 77% | 1.69 | 865 / 1118 |
adrenal gland | 100% | 872.29 | 258 / 258 | 73% | 1.86 | 169 / 230 |
esophagus | 100% | 609.86 | 1445 / 1445 | 70% | 1.53 | 128 / 183 |
skin | 91% | 384.13 | 1651 / 1809 | 78% | 1.98 | 367 / 472 |
lung | 98% | 298.38 | 566 / 578 | 68% | 1.40 | 785 / 1155 |
uterus | 100% | 424.85 | 170 / 170 | 65% | 1.34 | 298 / 459 |
bladder | 100% | 413.67 | 21 / 21 | 63% | 1.75 | 320 / 504 |
blood vessel | 100% | 542.20 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 514.84 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 100% | 901.63 | 802 / 803 | 0% | 0 | 0 / 0 |
adipose | 100% | 393.80 | 1201 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 711.82 | 832 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 3.45 | 75 / 80 |
lymph node | 0% | 0 | 0 / 0 | 93% | 2.12 | 27 / 29 |
peripheral blood | 52% | 140.79 | 485 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 51% | 0.92 | 23 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0070207 | Biological process | protein homotrimerization |
GO_0106121 | Biological process | positive regulation of cobalamin metabolic process |
GO_0106064 | Biological process | regulation of cobalamin metabolic process |
GO_0005739 | Cellular component | mitochondrion |
GO_0004474 | Molecular function | malate synthase activity |
GO_0047777 | Molecular function | (S)-citramalyl-CoA lyase activity |
GO_0016787 | Molecular function | hydrolase activity |
GO_0000287 | Molecular function | magnesium ion binding |
Gene name | CLYBL |
Protein name | Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9) Citramalyl-CoA lyase |
Synonyms | CLB |
Description | FUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism . Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway . The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite . Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate . Also displays malyl-CoA thioesterase activity . Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate . Also has very weak citramalate synthase activity in vitro . . |
Accessions | Q8N0X4 Q5JVC2 ENST00000425186.2 ENST00000693071.1 [Q8N0X4-2] ENST00000416504.5 ENST00000376355.7 [Q8N0X4-1] ENST00000376354.5 [Q8N0X4-2] ENST00000339105.9 [Q8N0X4-1] ENST00000419700.1 Q5JVC1 Q5JVC0 ENST00000443887.1 ENST00000689673.1 [Q8N0X4-1] Q5JVB9 |