CLYBL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070207Biological processprotein homotrimerization
GO_0106121Biological processpositive regulation of cobalamin metabolic process
GO_0106064Biological processregulation of cobalamin metabolic process
GO_0005739Cellular componentmitochondrion
GO_0004474Molecular functionmalate synthase activity
GO_0047777Molecular function(S)-citramalyl-CoA lyase activity
GO_0016787Molecular functionhydrolase activity
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameCLYBL
Protein nameCitramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)
Citramalyl-CoA lyase
SynonymsCLB
DescriptionFUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism . Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway . The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite . Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate . Also displays malyl-CoA thioesterase activity . Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate . Also has very weak citramalate synthase activity in vitro . .

AccessionsQ8N0X4
Q5JVC2
ENST00000425186.2
ENST00000693071.1 [Q8N0X4-2]
ENST00000416504.5
ENST00000376355.7 [Q8N0X4-1]
ENST00000376354.5 [Q8N0X4-2]
ENST00000339105.9 [Q8N0X4-1]
ENST00000419700.1
Q5JVC1
Q5JVC0
ENST00000443887.1
ENST00000689673.1 [Q8N0X4-1]
Q5JVB9