I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 28% ± 7% | |
| basal cell | 3 studies | 22% ± 8% | |
| squamous epithelial cell | 3 studies | 46% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 28% ± 7% | |
| basal cell | 3 studies | 22% ± 8% | |
| squamous epithelial cell | 3 studies | 46% ± 13% |
Insufficient scRNA-seq data for expression of CLCA4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 76% | 1848.05 | 16 / 21 | 52% | 36.91 | 261 / 504 |
| brain | 79% | 398.73 | 2075 / 2642 | 36% | 2.10 | 252 / 705 |
| intestine | 56% | 14587.13 | 538 / 966 | 45% | 28.68 | 236 / 527 |
| ureter | 0% | 0 | 0 / 0 | 100% | 32.27 | 1 / 1 |
| esophagus | 47% | 18855.55 | 678 / 1445 | 52% | 59.24 | 95 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 91.10 | 36 / 45 |
| prostate | 47% | 389.19 | 115 / 245 | 21% | 1.82 | 107 / 502 |
| skin | 58% | 264.28 | 1054 / 1809 | 10% | 0.58 | 45 / 472 |
| uterus | 4% | 250.29 | 7 / 170 | 52% | 45.36 | 239 / 459 |
| breast | 26% | 182.08 | 118 / 459 | 3% | 0.18 | 36 / 1118 |
| lung | 1% | 2.70 | 6 / 578 | 23% | 9.24 | 270 / 1155 |
| stomach | 3% | 101.60 | 10 / 359 | 21% | 10.02 | 60 / 286 |
| pancreas | 0% | 3.14 | 1 / 328 | 9% | 4.26 | 16 / 178 |
| ovary | 3% | 3.07 | 5 / 180 | 0% | 0.08 | 2 / 430 |
| spleen | 2% | 4.79 | 5 / 241 | 0% | 0 | 0 / 0 |
| adipose | 2% | 13.66 | 20 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 2% | 2.34 | 4 / 258 | 0% | 0 | 0 / 230 |
| kidney | 1% | 1.89 | 1 / 89 | 0% | 0.16 | 2 / 901 |
| thymus | 1% | 1.70 | 6 / 653 | 0% | 0.01 | 1 / 605 |
| muscle | 1% | 5.68 | 7 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 2.57 | 11 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 0.55 | 1 / 226 | 0% | 0.01 | 1 / 406 |
| peripheral blood | 1% | 2.11 | 5 / 929 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.35 | 2 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0006508 | Biological process | proteolysis |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0005229 | Molecular function | intracellularly calcium-gated chloride channel activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | CLCA4 |
| Protein name | Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) (Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form] Alternative protein CLCA4 |
| Synonyms | CaCC2 UNQ562/PRO1124 |
| Description | FUNCTION: May be involved in mediating calcium-activated chloride conductance. |
| Accessions | Q14CN2 ENST00000370563.3 [Q14CN2-1] L8ECE0 |
