CLCA2 | OmnibusX

Name	Number of supported studies	Average coverage
basal cell	4 studies	31% ± 14%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLCA2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	39%	7467.32	559 / 1445	61%	246.25	111 / 183
tonsil	0%	0	0 / 0	84%	246.19	38 / 45
skin	73%	5780.58	1329 / 1809	9%	9.23	44 / 472
uterus	2%	158.59	3 / 170	54%	160.74	250 / 459
bladder	14%	593.24	3 / 21	34%	73.88	172 / 504
lung	3%	32.59	19 / 578	37%	104.38	422 / 1155
breast	14%	292.61	66 / 459	19%	25.26	209 / 1118
prostate	17%	401.92	42 / 245	2%	0.54	8 / 502
pancreas	0%	0	0 / 328	7%	6.26	12 / 178
thymus	0%	0.82	1 / 653	4%	2.25	24 / 605
intestine	0%	1.70	2 / 966	4%	5.56	20 / 527
adipose	1%	23.05	18 / 1204	0%	0	0 / 0
stomach	1%	17.26	2 / 359	0%	0.47	1 / 286
adrenal gland	0%	0	0 / 258	0%	0.46	1 / 230
brain	0%	0.64	3 / 2642	0%	0.20	2 / 705
kidney	0%	0	0 / 89	0%	0.73	3 / 901
ovary	0%	0	0 / 180	0%	0.08	1 / 430
blood vessel	0%	4.41	2 / 1335	0%	0	0 / 0
muscle	0%	0.93	1 / 803	0%	0	0 / 0
peripheral blood	0%	1.53	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_1902476	Biological process	chloride transmembrane transport
GO_0007155	Biological process	cell adhesion
GO_0006508	Biological process	proteolysis
GO_0030054	Cellular component	cell junction
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0031965	Cellular component	nuclear membrane
GO_0005886	Cellular component	plasma membrane
GO_0070161	Cellular component	anchoring junction
GO_0009925	Cellular component	basal plasma membrane
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005254	Molecular function	chloride channel activity
GO_0005229	Molecular function	intracellularly calcium-gated chloride channel activity
GO_0046872	Molecular function	metal ion binding

Gene name	CLCA2
Protein name	Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form]
Synonyms	CACC3
Description	FUNCTION: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. .
Accessions	ENST00000370565.5 Q9UQC9

CLCA2 report