CHST3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST3 at tissue level.

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0005975Biological processcarbohydrate metabolic process
GO_0006044Biological processN-acetylglucosamine metabolic process
GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0006790Biological processsulfur compound metabolic process
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0008459Molecular functionchondroitin 6-sulfotransferase activity
GO_0050698Molecular functionproteoglycan sulfotransferase activity
GO_0001517Molecular functionN-acetylglucosamine 6-O-sulfotransferase activity

IV. Literature review

[source]
Gene nameCHST3
Protein nameCarbohydrate sulfotransferase 3 (EC 2.8.2.17) (EC 2.8.2.21) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (C6ST) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0)
Synonyms
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin . Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices . Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan . Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity). .

AccessionsQ7LGC8
ENST00000373115.5