CHST10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CHST10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST10 at tissue level.

III. Associated gene sets

GO_0030166Biological processproteoglycan biosynthetic process
GO_0007155Biological processcell adhesion
GO_0008209Biological processandrogen metabolic process
GO_0007612Biological processlearning
GO_0016051Biological processcarbohydrate biosynthetic process
GO_0007616Biological processlong-term memory
GO_0008210Biological processestrogen metabolic process
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0016232Molecular functionHNK-1 sulfotransferase activity
GO_0008146Molecular functionsulfotransferase activity

IV. Literature review

[source]
Gene nameCHST10
Protein nameCarbohydrate sulfotransferase 10
Carbohydrate sulfotransferase (EC 2.8.2.-)
Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK-1ST) (HNK1ST) (HuHNK-1ST)
Synonyms
DescriptionFUNCTION: Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis . Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components . Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones . .

AccessionsC9JI33
ENST00000409046.5
ENST00000435960.5
ENST00000418201.5
C9JUE4
ENST00000420858.5
ENST00000409701.5
B8ZZ48
ENST00000264249.8
C9JCK7
C9J5X0
ENST00000421474.5
ENST00000448989.5
C9JWY0
O43529