CELF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006376Biological processmRNA splice site recognition
GO_1902866Biological processregulation of retina development in camera-type eye
GO_0001701Biological processin utero embryonic development
GO_0060079Biological processexcitatory postsynaptic potential
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0007281Biological processgerm cell development
GO_0090394Biological processnegative regulation of excitatory postsynaptic potential
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0017148Biological processnegative regulation of translation
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0003729Molecular functionmRNA binding
GO_0042835Molecular functionBRE binding
GO_0036002Molecular functionpre-mRNA binding

IV. Literature review

[source]
Gene nameCELF4
Protein nameCUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4)
CUGBP Elav-like family member 4
CUGBP Elav-like family member 4 (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4)
SynonymsBRUNOL4
DescriptionFUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. .

AccessionsENST00000587819.5
B4DHA8
ENST00000593271.5
K7EJ26
K7EJD7
ENST00000587657.1
ENST00000589229.5
ENST00000587911.5
K7ERH1
ENST00000588597.5
M0QY66
Q9BZC1
ENST00000361795.9 [Q9BZC1-3]
A0A0C4DGR1
ENST00000586009.5
ENST00000588591.5
K7ENR2
K7EJK3
M0R137
ENST00000591282.5 [Q9BZC1-1]
ENST00000589386.5
ENST00000590112.5
A0A0A0MTT3
K7EJW4
K7EPX2
K7EQ97
ENST00000603232.6 [Q9BZC1-4]
ENST00000601019.5
ENST00000420428.7 [Q9BZC1-1]
ENST00000591287.5 [Q9BZC1-2]
ENST00000601392.5
ENST00000334919.9 [Q9BZC1-5]
ENST00000587924.1