CDK5RAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0045664Biological processregulation of neuron differentiation
GO_0045903Biological processpositive regulation of translational fidelity
GO_0035600Biological processtRNA methylthiolation
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0070900Biological processmitochondrial tRNA modification
GO_0005575Cellular componentcellular_component
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0019901Molecular functionprotein kinase binding
GO_0035597Molecular functionN6-isopentenyladenosine methylthiotransferase activity
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCDK5RAP1
Protein nameCDK5 regulatory subunit associated protein 1 isoform 2
CDK5 regulatory subunit associated protein 1
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase)
CDK5 regulatory subunit associated protein 1 isoform 1
SynonymsCGI-05
C20orf34
HSPC167
DescriptionFUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) . Essential for efficient and highly accurate protein translation by the ribosome . Specifically inhibits CDK5 activation by CDK5R1 . Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease . .

AccessionsENST00000427097.5
ENST00000357886.8 [Q96SZ6-1]
ENST00000346416.7 [Q96SZ6-3]
ENST00000339269.5 [Q96SZ6-4]
ENST00000473997.5 [Q96SZ6-2]
Q96SZ6
H0Y721
A0A0S2Z5J9
A0A0S2Z592