CARS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006423Biological processcysteinyl-tRNA aminoacylation
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0004817Molecular functioncysteine-tRNA ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCARS2
Protein nameProbable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
Cysteinyl-tRNA synthetase 2, mitochondrial
SynonymsOK/SW-cl.10
DescriptionFUNCTION: Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). .; FUNCTION: In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides . CysSSHs behave as potent antioxidants and cellular protectants . .

AccessionsENST00000539269.5
H0YFF0
H0YFV1
ENST00000542709.5
ENST00000537394.5
A0A087WWV1
ENST00000537743.1
Q9HA77
H0YGF2
F5H579
ENST00000620794.1
F5H623
ENST00000487253.6
ENST00000257347.9