CARMIL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CARMIL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CARMIL2 at tissue level.

III. Associated gene sets

GO_0090091Biological processpositive regulation of extracellular matrix disassembly
GO_0061339Biological processestablishment or maintenance of monopolar cell polarity
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_1900029Biological processpositive regulation of ruffle assembly
GO_2000813Biological processnegative regulation of barbed-end actin filament capping
GO_0051639Biological processactin filament network formation
GO_1902745Biological processpositive regulation of lamellipodium organization
GO_0030335Biological processpositive regulation of cell migration
GO_0044319Biological processwound healing, spreading of cells
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0016477Biological processcell migration
GO_0001726Cellular componentruffle
GO_0005886Cellular componentplasma membrane
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0016020Cellular componentmembrane
GO_0044354Cellular componentmacropinosome
GO_0031252Cellular componentcell leading edge
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0015629Cellular componentactin cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005543Molecular functionphospholipid binding
GO_0044877Molecular functionprotein-containing complex binding

IV. Literature review

[source]
Gene nameCARMIL2
Protein nameRLTPR protein
Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
Capping protein regulator and myosin 1 linker 2
SynonymsLRRC16C
RLTPR
DescriptionFUNCTION: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization . Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations . Involved as well in cell migration and invadopodia formation during wound healing . Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells . .

AccessionsA0A8Q3SII9
ENST00000696175.1
ENST00000602563.1
ENST00000334583.11 [Q6F5E8-1]
ENST00000696176.1
Q86XL4
Q6F5E8
ENST00000602924.2
A0A8Q3SIB7
ENST00000696044.1
R4GNC4
ENST00000545661.5 [Q6F5E8-2]
A0A8Q3WLI1
A0A8Q3WKY0