C10orf90 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	16 studies	70% ± 20%	Explore
oligodendrocyte precursor cell	12 studies	47% ± 21%	Explore
astrocyte	6 studies	32% ± 18%	Explore
GABAergic neuron	3 studies	21% ± 6%	Explore

Name	Number of supported studies	Average coverage
brain	9 studies	36% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	562.22	2572 / 2642	86%	3.75	603 / 705
skin	67%	79.95	1205 / 1809	92%	12.54	435 / 472
eye	0%	0	0 / 0	100%	17.04	80 / 80
breast	65%	135.68	300 / 459	9%	0.35	103 / 1118
adipose	33%	33.46	393 / 1204	0%	0	0 / 0
thymus	19%	19.06	126 / 653	7%	0.19	44 / 605
intestine	11%	10.63	108 / 966	0%	0.03	2 / 527
liver	0%	0	0 / 226	5%	0.13	19 / 406
lung	0%	0	0 / 578	5%	0.10	54 / 1155
esophagus	2%	1.31	22 / 1445	3%	0.04	5 / 183
kidney	3%	1.92	3 / 89	1%	0.02	5 / 901
uterus	1%	0.39	1 / 170	3%	0.06	15 / 459
bladder	0%	0	0 / 21	3%	0.10	17 / 504
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
prostate	2%	1.29	4 / 245	0%	0.01	1 / 502
adrenal gland	0%	0	0 / 258	1%	0.01	2 / 230
pancreas	1%	0.31	2 / 328	0%	0	0 / 178
ovary	1%	0.28	1 / 180	0%	0	0 / 430
stomach	0%	0	0 / 359	0%	0.00	1 / 286
heart	0%	0.31	3 / 861	0%	0	0 / 0
blood vessel	0%	0.21	4 / 1335	0%	0	0 / 0
muscle	0%	0.16	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0016567	Biological process	protein ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0046599	Biological process	regulation of centriole replication
GO_0050821	Biological process	protein stabilization
GO_0005814	Cellular component	centriole
GO_0005813	Cellular component	centrosome
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0008017	Molecular function	microtubule binding

Gene name	C10orf90
Protein name	Chromosome 10 open reading frame 90 (E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS)
Synonyms	FATS
Description	FUNCTION: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). .
Accessions	A0A0C4DGS3 ENST00000424927.5 ENST00000480379.5 ENST00000284694.11 [Q96M02-1] S4R3Q7 ENST00000463082.1 ENST00000432642.5 Q96M02 Q5T025 H7C3F8 S4R3N7 A0A0A0MSX2 ENST00000356858.7 ENST00000488181.3

C10orf90 report