BRF2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BRF2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BRF2 at tissue level.

III. Associated gene sets

GO_0034599Biological processcellular response to oxidative stress
GO_0070897Biological processtranscription preinitiation complex assembly
GO_0006359Biological processregulation of transcription by RNA polymerase III
GO_0006352Biological processDNA-templated transcription initiation
GO_0097550Cellular componenttranscription preinitiation complex
GO_0005654Cellular componentnucleoplasm
GO_0000126Cellular componenttranscription factor TFIIIB complex
GO_0005634Cellular componentnucleus
GO_0017025Molecular functionTBP-class protein binding
GO_0046872Molecular functionmetal ion binding
GO_0001006Molecular functionRNA polymerase III type 3 promoter sequence-specific DNA binding

IV. Literature review

[source]
Gene nameBRF2
Protein nameTranscription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU)
Transcription factor IIIB 50 kDa subunit (B-related factor 2)
BRF2 RNA polymerase III transcription initiation factor subunit
SynonymsBRFU
PRO1470
DescriptionFUNCTION: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites . Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress . Down-regulates expression of target genes in response to oxidative stress . Overexpression protects cells against apoptosis in response to oxidative stress . .

AccessionsE5RGF6
Q9HAW0
E5RGX1
ENST00000220659.11 [Q9HAW0-1]
ENST00000522539.1
ENST00000520601.5
ENST00000521170.5