BPNT1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BPNT1 at tissue level.

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0050427Biological process3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0007399Biological processnervous system development
GO_0005829Cellular componentcytosol
GO_0004441Molecular functioninositol-1,4-bisphosphate 1-phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0008441Molecular function3'(2'),5'-bisphosphate nucleotidase activity

IV. Literature review

[source]
Gene nameBPNT1
Protein name3'(2'), 5'-bisphosphate nucleotidase 1
3'(2'),5'-bisphosphate nucleotidase 1 (Bisphosphate 3'-nucleotidase 1)
3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (HsPIP) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57)
Synonyms
DescriptionFUNCTION: Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate . Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate . .

AccessionsENST00000414869.6 [O95861-4]
F8VVW8
ENST00000354807.7
F8VZG4
F8VRY7
ENST00000463953.5
ENST00000498791.6
O95861
ENST00000322067.12 [O95861-1]
ENST00000544404.5 [O95861-3]
F8W1J0
ENST00000480959.6
ENST00000498237.3
ENST00000469520.6 [O95861-1]
A6NF51