BPHL | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell of proximal tubule	6 studies	28% ± 8%	Explore
hepatocyte	4 studies	30% ± 16%	Explore
epithelial cell	3 studies	35% ± 15%	Explore
ciliated cell	3 studies	20% ± 2%	Explore
GABAergic neuron	3 studies	28% ± 6%	Explore
glutamatergic neuron	3 studies	30% ± 10%	Explore
adipocyte	3 studies	20% ± 2%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	22% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	346.13	245 / 245	100%	8.35	500 / 502
breast	100%	615.82	459 / 459	99%	9.00	1110 / 1118
liver	100%	1556.32	226 / 226	99%	18.10	403 / 406
brain	99%	431.27	2626 / 2642	100%	7.37	704 / 705
ovary	99%	347.32	179 / 180	100%	8.11	429 / 430
skin	100%	489.64	1809 / 1809	99%	9.47	466 / 472
pancreas	100%	327.71	328 / 328	98%	4.99	175 / 178
stomach	100%	300.68	359 / 359	98%	6.28	280 / 286
bladder	100%	458.43	21 / 21	97%	7.37	491 / 504
intestine	100%	467.87	966 / 966	97%	6.92	510 / 527
lung	98%	228.12	566 / 578	98%	6.99	1133 / 1155
kidney	100%	1985.58	89 / 89	96%	9.48	862 / 901
esophagus	100%	344.84	1442 / 1445	95%	4.64	173 / 183
uterus	100%	421.37	170 / 170	94%	5.86	432 / 459
adrenal gland	100%	618.83	258 / 258	87%	5.24	200 / 230
thymus	100%	300.78	651 / 653	82%	2.93	497 / 605
adipose	100%	605.77	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.79	1 / 1
spleen	100%	190.88	240 / 241	0%	0	0 / 0
muscle	100%	306.75	799 / 803	0%	0	0 / 0
blood vessel	99%	244.14	1325 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	4.39	44 / 45
eye	0%	0	0 / 0	96%	8.70	77 / 80
heart	95%	287.28	820 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	3.55	25 / 29
peripheral blood	35%	93.98	329 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0009636	Biological process	response to toxic substance
GO_0006805	Biological process	xenobiotic metabolic process
GO_0006520	Biological process	amino acid metabolic process
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005739	Cellular component	mitochondrion
GO_0047658	Molecular function	alpha-amino-acid esterase activity

Gene name	BPHL
Protein name	Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA) BPHL protein (Biphenyl hydrolase like) (Biphenyl hydrolase-like (Serine hydrolase breast epithelial mucin-associated antigen), isoform CRA_a) Biphenyl hydrolase like (cDNA FLJ58913, highly similar to Valacyclovir hydrolase) Biphenyl hydrolase like
Synonyms	MCNAA hCG_22877
Description	FUNCTION: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. .
Accessions	F2Z2Q1 ENST00000380368.6 ENST00000430655.6 ENST00000433912.5 Q49AI2 Q86WA6 ENST00000423798.1 H7C0M3 ENST00000424847.6 ENST00000380379.10 [Q86WA6-1] B4DML3 ENST00000434640.5 [Q86WA6-2] ENST00000380375.4 [Q86WA6-2]

BPHL report