BMT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032259Biological processmethylation
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_1903432Biological processregulation of TORC1 signaling
GO_0061431Biological processcellular response to methionine
GO_0005829Cellular componentcytosol
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0008168Molecular functionmethyltransferase activity

IV. Literature review

[source]
Gene nameBMT2
Protein nameS-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-)
Base methyltransferase of 25S rRNA 2 homolog
SynonymsSAMTOR
C7orf60
DescriptionFUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes . Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling . Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). .

FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. .

AccessionsB4DST1
H0Y6Y0
ENST00000297145.9
Q1RMZ1
ENST00000432572.1