B4GALT6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010706Biological processganglioside biosynthetic process via lactosylceramide
GO_0005975Biological processcarbohydrate metabolic process
GO_0042551Biological processneuron maturation
GO_0006486Biological processprotein glycosylation
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0022010Biological processcentral nervous system myelination
GO_0021955Biological processcentral nervous system neuron axonogenesis
GO_0070085Biological processglycosylation
GO_0001572Biological processlactosylceramide biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005794Cellular componentGolgi apparatus
GO_0008378Molecular functiongalactosyltransferase activity
GO_0008489Molecular functionUDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameB4GALT6
Protein nameBeta-1,4-galactosyltransferase 6
Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6)
Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)
SynonymshCG_25475
DescriptionFUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) . LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). .

FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .

FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .

AccessionsENST00000237019.11
J3QQY9
ENST00000579372.1
ENST00000383131.3 [Q9UBX8-2]
ENST00000306851.10 [Q9UBX8-1]
G3XA83
Q9UBX8
Q6NT00