AWAT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AWAT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AWAT2 at tissue level.

III. Associated gene sets

GO_0036155Biological processacylglycerol acyl-chain remodeling
GO_0001523Biological processretinoid metabolic process
GO_0006640Biological processmonoacylglycerol biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0010025Biological processwax biosynthetic process
GO_0042572Biological processretinol metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0050252Molecular functionretinol O-fatty-acyltransferase activity
GO_0003846Molecular function2-acylglycerol O-acyltransferase activity
GO_0047196Molecular functionlong-chain-alcohol O-fatty-acyltransferase activity
GO_0004144Molecular functiondiacylglycerol O-acyltransferase activity

IV. Literature review

[source]
Gene nameAWAT2
Protein nameAcyl-CoA wax alcohol acyltransferase 2 (EC 2.3.1.75) (11-cis-specific retinyl-ester synthase) (11-cis-RE-synthase) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diacylglycerol O-acyltransferase 2-like protein 4) (EC 2.3.1.20) (Diacylglycerol O-acyltransferase candidate 4) (hDC4) (Long-chain-alcohol O-fatty-acyltransferase 2) (Multifunctional O-acyltransferase) (Wax synthase) (hWS)
Acyl-CoA wax alcohol acyltransferase 2
SynonymsWS
DGAT2L4
DC4
MFAT
DescriptionFUNCTION: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters . Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively . Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells . Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates . .

AccessionsH0YAL0
ENST00000440401.1
ENST00000276101.7
Q6E213