ATP8B3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATP8B3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP8B3 at tissue level.

III. Associated gene sets

GO_0007339Biological processbinding of sperm to zona pellucida
GO_0007030Biological processGolgi organization
GO_0045332Biological processphospholipid translocation
GO_0051649Biological processestablishment of localization in cell
GO_0005802Cellular componenttrans-Golgi network
GO_0002080Cellular componentacrosomal membrane
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0090556Molecular functionphosphatidylserine floppase activity
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0000287Molecular functionmagnesium ion binding
GO_0140326Molecular functionATPase-coupled intramembrane lipid transporter activity

IV. Literature review

[source]
Gene nameATP8B3
Protein namePhospholipid-transporting ATPase IK (EC 7.6.2.1) (ATPase class I type 8B member 3)
ATPase phospholipid transporting 8B3
SynonymsFOS37502_2
ATP1K
DescriptionFUNCTION: P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. .

AccessionsENST00000526847.1
F5GZM8
F5H3R9
ENST00000525591.5 [O60423-3]
H0YFS1
ENST00000526092.6
O60423
ENST00000587160.2
ENST00000531925.5
ENST00000310127.10 [O60423-2]
K7EJ52