ATP6V1C2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP6V1C2 at tissue level.

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0016241Biological processregulation of macroautophagy
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0000221Cellular componentvacuolar proton-transporting V-type ATPase, V1 domain
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005765Cellular componentlysosomal membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameATP6V1C2
Protein nameV-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2)
V-type proton ATPase subunit C
Synonyms
DescriptionFUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). .

FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. .

FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. .

AccessionsENST00000648362.1
ENST00000272238.9 [Q8NEY4-1]
ENST00000635370.1
ENST00000381661.3 [Q8NEY4-2]
Q8NEY4
A0A3B3IRZ7
A0A0U1RR16