ATP12A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATP12A at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0036376Biological processsodium ion export across plasma membrane
GO_0006885Biological processregulation of pH
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0010248Biological processestablishment or maintenance of transmembrane electrochemical gradient
GO_0030007Biological processintracellular potassium ion homeostasis
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005889Cellular componentpotassium:proton exchanging ATPase complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005391Molecular functionP-type sodium:potassium-exchanging transporter activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0008900Molecular functionP-type potassium:proton transporter activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameATP12A
Protein namePotassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)
SynonymsATP1AL1
DescriptionFUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment . Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance . .

AccessionsENST00000218548.10 [P54707-2]
P54707
ENST00000381946.5 [P54707-1]