ATG9B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATG9B at tissue level.

III. Associated gene sets

GO_0000422Biological processautophagy of mitochondrion
GO_0017121Biological processplasma membrane phospholipid scrambling
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0061709Biological processreticulophagy
GO_0060349Biological processbone morphogenesis
GO_0097300Biological processprogrammed necrotic cell death
GO_0000045Biological processautophagosome assembly
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0034045Cellular componentphagophore assembly site membrane
GO_0000139Cellular componentGolgi membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0017128Molecular functionphospholipid scramblase activity

IV. Literature review

[source]
Gene nameATG9B
Protein nameAutophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE)
SynonymsNOS3AS
APG9L2
DescriptionFUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). .

AccessionsENST00000469530.4 [Q674R7-1]
ENST00000605952.5 [Q674R7-1]
ENST00000639579.2 [Q674R7-1]
Q674R7