ASRGL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033345Biological processasparagine catabolic process via L-aspartate
GO_0006508Biological processproteolysis
GO_0001917Cellular componentphotoreceptor inner segment
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004067Molecular functionasparaginase activity
GO_0008798Molecular functionbeta-aspartyl-peptidase activity
GO_0003948Molecular functionN4-(beta-N-acetylglucosaminyl)-L-asparaginase activity

IV. Literature review

[source]
Gene nameASRGL1
Protein nameIsoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]
Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase)
Asparaginase and isoaspartyl peptidase 1
Isoaspartyl peptidase/L-asparaginase (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase)
SynonymsALP
CRASH
DescriptionFUNCTION: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. .

AccessionsQ7L266
ENST00000534571.5
ENST00000528206.1
ENST00000534183.5
A0A087WUG3
ENST00000526096.2
Q9BRH2
A0A087X1T8
ENST00000301776.9 [Q7L266-1]
E9PJK6
A0A087WZI5
ENST00000628829.2
ENST00000415229.6 [Q7L266-1]
ENST00000529226.3