AP4S1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0008104Biological processprotein localization
GO_0016192Biological processvesicle-mediated transport
GO_0006605Biological processprotein targeting
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005802Cellular componenttrans-Golgi network
GO_0030124Cellular componentAP-4 adaptor complex
GO_0031904Cellular componentendosome lumen

IV. Literature review

[source]
Gene nameAP4S1
Protein nameAP-4 complex subunit sigma-1
AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin)
Adaptor related protein complex 4 subunit sigma 1
AP complex subunit sigma
SynonymshCG_2013646
DescriptionFUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways . AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). .

AccessionsA0A8C8KBR5
ENST00000557346.6 [Q9Y587-1]
A0A5F9ZI62
ENST00000542754.7 [Q9Y587-1]
G3V4P7
ENST00000673001.1
ENST00000557346
ENST00000554609.6 [Q9Y587-3]
ENST00000556232.6
ENST00000555417.6 [Q9Y587-1]
ENST00000554345.6 [Q9Y587-2]
A0A5F9ZHV3
ENST00000313566.11
ENST00000673317.1
ENST00000555417
A0A8C8KCP6
ENST00000672143.1
Q9Y587
ENST00000554609
A0A0G2JL90
ENST00000334725.8 [Q9Y587-4]
A0A5F9ZH42
G3V3X7
ENST00000216366.9
G3V5J6