AOX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006629Biological processlipid metabolic process
GO_0005829Cellular componentcytosol
GO_0070062Cellular componentextracellular exosome
GO_0042803Molecular functionprotein homodimerization activity
GO_0071949Molecular functionFAD binding
GO_0051287Molecular functionNAD binding
GO_0051537Molecular function2 iron, 2 sulfur cluster binding
GO_0005506Molecular functioniron ion binding
GO_0043546Molecular functionmolybdopterin cofactor binding
GO_0004031Molecular functionaldehyde oxidase activity
GO_0042802Molecular functionidentical protein binding
GO_0050660Molecular functionflavin adenine dinucleotide binding

IV. Literature review

[source]
Gene nameAOX1
Protein namealdehyde oxidase (EC 1.2.3.1)
Aldehyde oxidase 1
Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-)
SynonymsAO
DescriptionFUNCTION: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. .

AccessionsENST00000454629.1
ENST00000260930.10
H7C3Q1
H7BXF7
ENST00000439380.1
Q06278
ENST00000374700.7
C9J244
A0A286LWX1