ANKRD9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ANKRD9 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006878Biological processintracellular copper ion homeostasis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031466Cellular componentCul5-RING ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0031410Cellular componentcytoplasmic vesicle
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity

IV. Literature review

[source]
Gene nameANKRD9
Protein nameAnkyrin repeat domain-containing protein 9
Ankyrin repeat domain 9
Synonyms
DescriptionFUNCTION: Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly . Implicated in different cellular processes, like copper homeostasis and cell proliferation . .

AccessionsENST00000559651.1
H0YM08
Q96BM1
H0YNN1
ENST00000557902.1
ENST00000560748.5
ENST00000559404.5
ENST00000286918.9