AMACR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AMACR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AMACR at tissue level.

III. Associated gene sets

GO_0006699Biological processbile acid biosynthetic process
GO_0008206Biological processbile acid metabolic process
GO_0033540Biological processfatty acid beta-oxidation using acyl-CoA oxidase
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0008111Molecular functionalpha-methylacyl-CoA racemase activity

IV. Literature review

[source]
Gene nameAMACR
Protein nameAlpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase)
Alpha-methylacyl-CoA racemase
Synonyms
DescriptionFUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters . Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs . .

AccessionsENST00000335606.11 [Q9UHK6-1]
Q9UHK6
D6RB81
ENST00000506639.5 [Q9UHK6-2]
ENST00000502637.5
ENST00000382085.7 [Q9UHK6-5]
ENST00000382072.6 [Q9UHK6-4]