I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 5 studies | 49% ± 14% | |
| retinal cone cell | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 5 studies | 49% ± 14% | |
| retinal cone cell | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 2413.92 | 89 / 89 | 81% | 20.11 | 732 / 901 |
| liver | 56% | 658.36 | 127 / 226 | 57% | 3.24 | 231 / 406 |
| muscle | 100% | 5173.26 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 6662.81 | 827 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 3.44 | 14 / 29 |
| pancreas | 0% | 0 | 0 / 328 | 46% | 1.26 | 82 / 178 |
| stomach | 28% | 406.74 | 100 / 359 | 15% | 0.54 | 43 / 286 |
| skin | 33% | 1046.66 | 594 / 1809 | 10% | 0.28 | 47 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 40% | 1.20 | 18 / 45 |
| bladder | 5% | 15.24 | 1 / 21 | 22% | 1.21 | 112 / 504 |
| breast | 3% | 13.47 | 12 / 459 | 24% | 0.45 | 272 / 1118 |
| ovary | 0% | 0 | 0 / 180 | 23% | 0.54 | 100 / 430 |
| uterus | 0% | 0 | 0 / 170 | 23% | 0.93 | 106 / 459 |
| intestine | 8% | 62.01 | 74 / 966 | 15% | 0.32 | 81 / 527 |
| lung | 1% | 14.68 | 5 / 578 | 21% | 0.59 | 240 / 1155 |
| esophagus | 1% | 3.87 | 9 / 1445 | 17% | 0.34 | 32 / 183 |
| peripheral blood | 15% | 117.72 | 136 / 929 | 0% | 0 | 0 / 0 |
| adipose | 14% | 101.02 | 170 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 2% | 16.27 | 13 / 653 | 9% | 0.26 | 52 / 605 |
| brain | 0% | 0 | 0 / 2642 | 10% | 0.43 | 68 / 705 |
| spleen | 2% | 10.46 | 6 / 241 | 0% | 0 | 0 / 0 |
| prostate | 1% | 5.63 | 3 / 245 | 1% | 0.02 | 5 / 502 |
| blood vessel | 1% | 25.06 | 19 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 1% | 0.03 | 3 / 230 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030010 | Biological process | establishment of cell polarity |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_1905223 | Biological process | epicardium morphogenesis |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0003308 | Biological process | negative regulation of Wnt signaling pathway involved in heart development |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0055013 | Biological process | cardiac muscle cell development |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ALPK2 |
| Protein name | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) |
| Synonyms | HAK |
| Description | FUNCTION: Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation . Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling . . |
| Accessions | ENST00000361673.4 Q86TB3 |
