AKR1C4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AKR1C4 at tissue level.

III. Associated gene sets

GO_0044597Biological processdaunorubicin metabolic process
GO_0008209Biological processandrogen metabolic process
GO_0044598Biological processdoxorubicin metabolic process
GO_0071395Biological processcellular response to jasmonic acid stimulus
GO_0042448Biological processprogesterone metabolic process
GO_0015721Biological processbile acid and bile salt transport
GO_0001523Biological processretinoid metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0006699Biological processbile acid biosynthetic process
GO_0008202Biological processsteroid metabolic process
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0015125Molecular functionbile acid transmembrane transporter activity
GO_0047024Molecular function5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO_0047086Molecular functionketosteroid monooxygenase activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0047044Molecular functionandrostan-3-alpha,17-beta-diol dehydrogenase activity
GO_0016655Molecular functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO_0047023Molecular functionandrosterone dehydrogenase activity
GO_0009055Molecular functionelectron transfer activity
GO_0004033Molecular functionaldo-keto reductase (NADPH) activity
GO_0047035Molecular functiontestosterone dehydrogenase (NAD+) activity
GO_0001758Molecular functionretinal dehydrogenase activity
GO_0032052Molecular functionbile acid binding
GO_0047045Molecular functiontestosterone 17-beta-dehydrogenase (NADP+) activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0035410Molecular functiondihydrotestosterone 17-beta-dehydrogenase activity
GO_0047743Molecular functionchlordecone reductase activity

IV. Literature review

[source]
Gene nameAKR1C4
Protein nameAldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA)
SynonymsCHDR
DescriptionFUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as an NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain . Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH . Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity . Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) . Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency . Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids . Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route . .

AccessionsP17516
ENST00000380448.5
ENST00000263126.3