AKR1B15 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AKR1B15 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AKR1B15 at tissue level.

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_0042572Biological processretinol metabolic process
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0047045Molecular functiontestosterone 17-beta-dehydrogenase (NADP+) activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0047655Molecular functionallyl-alcohol dehydrogenase activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0052650Molecular functionall-trans-retinol dehydrogenase (NADP+) activity
GO_0047886Molecular functionfarnesol dehydrogenase activity

IV. Literature review

[source]
Gene nameAKR1B15
Protein nameAldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64)
Synonyms
DescriptionFUNCTION: [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds . In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs . Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal . May play a physiological role in retinoid metabolism . .; FUNCTION: [Isoform 2]: No oxidoreductase activity observed with the tested substrates. .

AccessionsENST00000457545.7 [C9JRZ8-2]
ENST00000652743.1 [C9JRZ8-1]
C9JRZ8
ENST00000423958.2 [C9JRZ8-2]