AK9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046940Biological processnucleoside monophosphate phosphorylation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004017Molecular functionadenylate kinase activity
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_0050145Molecular functionnucleoside monophosphate kinase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameAK9
Protein nameAdenylate kinase 8 (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8)
Adenylate kinase 9
Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2)
Cilia- and flagella-associated protein 206
nucleoside-diphosphate kinase (EC 2.7.4.6)
SynonymsC6orf224
AKD2
AKD1
C6orf199
DescriptionFUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. .

FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. .

AccessionsA0A075B7F5
H0YCD1
J3KP89
ENST00000355283.1 [Q5TCS8-5]
ENST00000524674.5
H7C505
ENST00000491875.5
E9PPU7
ENST00000490722.1
ENST00000470564.5
ENST00000605986.5
ENST00000424296.7 [Q5TCS8-4]
H7C517
ENST00000285397.9 [Q5TCS8-2]
ENST00000368948.6
ENST00000448084.6
H0Y8C5
ENST00000532976.1
E9PPM3
Q5TCS8