AGXT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001299Biological processN(omega),N(omega)-dimethyl-L-arginine catabolic process
GO_0019265Biological processglycine biosynthetic process, by transamination of glyoxylate
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0009436Biological processglyoxylate catabolic process
GO_0019481Biological processL-alanine catabolic process, by transamination
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0047305Molecular function(R)-3-amino-2-methylpropionate-pyruvate transaminase activity
GO_0016223Molecular functionbeta-alanine-pyruvate transaminase activity
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0008453Molecular functionalanine-glyoxylate transaminase activity

IV. Literature review

[source]
Gene nameAGXT2
Protein nameAlanine--glyoxylate aminotransferase 2, mitochondrial (EC 2.6.1.18) (EC 2.6.1.40) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-3-aminoisobutyrate-pyruvate aminotransferase) (D-AIBAT) (D-beta-aminoisobutyrate-pyruvate aminotransferase)
Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (EC 2.6.1.18) (D-3-aminoisobutyrate-pyruvate aminotransferase) (D-AIBAT) (D-beta-aminoisobutyrate-pyruvate aminotransferase)
SynonymsAGT2
DescriptionFUNCTION: Multifunctional aminotransferase with a broad substrate specifcity . Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine . Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (By similarity). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) . ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure . .

AccessionsENST00000618015.4 [Q9BYV1-2]
Q9BYV1
B2RBJ5
ENST00000231420.11 [Q9BYV1-1]
ENST00000510428.1 [Q9BYV1-2]