I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 4 studies | 34% ± 6% | |
| epithelial cell | 3 studies | 25% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 4 studies | 34% ± 6% | |
| epithelial cell | 3 studies | 25% ± 8% |
Insufficient scRNA-seq data for expression of AGMAT at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2636.80 | 226 / 226 | 96% | 60.68 | 389 / 406 |
| kidney | 100% | 6007.16 | 89 / 89 | 74% | 30.14 | 671 / 901 |
| intestine | 61% | 405.74 | 588 / 966 | 96% | 41.87 | 507 / 527 |
| stomach | 53% | 44.62 | 191 / 359 | 95% | 39.18 | 271 / 286 |
| bladder | 57% | 30.19 | 12 / 21 | 61% | 14.59 | 306 / 504 |
| pancreas | 76% | 39.42 | 249 / 328 | 41% | 4.53 | 73 / 178 |
| prostate | 71% | 36.89 | 174 / 245 | 37% | 3.43 | 187 / 502 |
| adrenal gland | 99% | 127.52 | 255 / 258 | 7% | 0.67 | 15 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.84 | 29 / 29 |
| muscle | 100% | 775.67 | 801 / 803 | 0% | 0 | 0 / 0 |
| spleen | 99% | 149.17 | 239 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 35% | 21.78 | 505 / 1445 | 56% | 12.57 | 102 / 183 |
| peripheral blood | 83% | 151.99 | 770 / 929 | 0% | 0 | 0 / 0 |
| uterus | 41% | 20.34 | 70 / 170 | 42% | 4.37 | 191 / 459 |
| thymus | 70% | 33.38 | 459 / 653 | 12% | 1.24 | 75 / 605 |
| brain | 69% | 67.88 | 1814 / 2642 | 4% | 0.29 | 26 / 705 |
| lung | 21% | 8.32 | 123 / 578 | 32% | 5.05 | 372 / 1155 |
| breast | 37% | 15.25 | 168 / 459 | 16% | 1.24 | 181 / 1118 |
| skin | 35% | 33.02 | 628 / 1809 | 15% | 1.36 | 73 / 472 |
| ovary | 11% | 4.12 | 20 / 180 | 31% | 2.72 | 135 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 3.59 | 19 / 45 |
| adipose | 20% | 8.51 | 241 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 6% | 2.50 | 75 / 1335 | 0% | 0 | 0 / 0 |
| heart | 3% | 0.94 | 27 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0000050 | Biological process | urea cycle |
| GO_0033389 | Biological process | putrescine biosynthetic process from arginine, using agmatinase |
| GO_0097055 | Biological process | agmatine biosynthetic process |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0047972 | Molecular function | guanidinopropionase activity |
| GO_0047971 | Molecular function | guanidinobutyrase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0008783 | Molecular function | agmatinase activity |
| GO_0004053 | Molecular function | arginase activity |
| Gene name | AGMAT |
| Protein name | Guanidino acid hydrolase, mitochondrial (EC 3.5.3.-) (Arginase, mitochondrial) (EC 3.5.3.1) (Guanidinobutyrase, mitochondrial) (EC 3.5.3.7) (Guanidinopropionase, mitochondrial) (EC 3.5.3.17) |
| Synonyms | GDAH |
| Description | FUNCTION: Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency. . |
| Accessions | Q9BSE5 ENST00000375826.4 |
