AGBL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0035609Biological processC-terminal protein deglutamylation
GO_0006508Biological processproteolysis
GO_0035610Biological processprotein side chain deglutamylation
GO_0035611Biological processprotein branching point deglutamylation
GO_0035608Biological processprotein deglutamylation
GO_0030496Cellular componentmidbody
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0045171Cellular componentintercellular bridge
GO_0072686Cellular componentmitotic spindle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004181Molecular functionmetallocarboxypeptidase activity
GO_0008270Molecular functionzinc ion binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameAGBL5
Protein nameCytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5)
AGBL carboxypeptidase 5
SynonymsCCP5
DescriptionFUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. .

AccessionsC9JHM6
ENST00000437006.1
ENST00000451003.5
ENST00000453161.5
ENST00000441931.1
H7C1L5
ENST00000323064.12 [Q8NDL9-3]
Q8NDL9
ENST00000487078.5 [Q8NDL9-2]
ENST00000421915.5
C9JCE1
C9JTY1
ENST00000360131.5 [Q8NDL9-1]
C9JQG9