Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 5 studies | 24% ± 9% | |
| astrocyte | 4 studies | 29% ± 16% | |
| glutamatergic neuron | 4 studies | 42% ± 19% | |
| endothelial cell | 3 studies | 18% ± 1% | |
| adipocyte | 3 studies | 20% ± 2% | |
| GABAergic neuron | 3 studies | 44% ± 10% | |
| interneuron | 3 studies | 43% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 40% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 80.66 | 2607 / 2642 | 97% | 2.66 | 682 / 705 |
| prostate | 100% | 81.63 | 245 / 245 | 87% | 1.72 | 437 / 502 |
| kidney | 100% | 99.82 | 89 / 89 | 84% | 4.11 | 754 / 901 |
| thymus | 100% | 79.29 | 652 / 653 | 82% | 1.45 | 494 / 605 |
| ovary | 100% | 108.72 | 180 / 180 | 62% | 1.08 | 265 / 430 |
| liver | 100% | 46.19 | 225 / 226 | 60% | 1.51 | 244 / 406 |
| pancreas | 100% | 69.80 | 327 / 328 | 58% | 0.95 | 103 / 178 |
| adrenal gland | 100% | 56.66 | 257 / 258 | 51% | 0.80 | 118 / 230 |
| breast | 100% | 82.32 | 459 / 459 | 48% | 0.81 | 540 / 1118 |
| skin | 94% | 37.90 | 1709 / 1809 | 45% | 0.77 | 212 / 472 |
| uterus | 99% | 98.74 | 169 / 170 | 40% | 0.71 | 183 / 459 |
| lung | 100% | 92.49 | 577 / 578 | 35% | 0.60 | 404 / 1155 |
| bladder | 100% | 63.24 | 21 / 21 | 23% | 0.35 | 117 / 504 |
| esophagus | 98% | 62.19 | 1409 / 1445 | 21% | 0.32 | 39 / 183 |
| stomach | 98% | 45.69 | 352 / 359 | 20% | 0.31 | 57 / 286 |
| intestine | 99% | 50.44 | 954 / 966 | 16% | 0.24 | 82 / 527 |
| spleen | 100% | 87.71 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 74.62 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 78.04 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 99% | 64.96 | 797 / 803 | 0% | 0 | 0 / 0 |
| heart | 92% | 33.98 | 793 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 28% | 48.43 | 258 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 0.38 | 8 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 20% | 0.33 | 9 / 45 |
| eye | 0% | 0 | 0 / 0 | 19% | 0.23 | 15 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006508 | Biological process | proteolysis |
| GO_0005829 | Cellular component | cytosol |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0004181 | Molecular function | metallocarboxypeptidase activity |
| Gene name | AGBL3 |
| Protein name | Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3) (Protein deglutamylase CCP3) AGBL carboxypeptidase 3 |
| Synonyms | CCP3 |
| Description | FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins. .; FUNCTION: [Isoform 2]: Metallocarboxypeptidase that mediates tubulin deglutamylation. . |
| Accessions | F8W7R4 Q8NEM8 ENST00000275763.10 [Q8NEM8-2] F8W6Y5 ENST00000436302.6 [Q8NEM8-4] ENST00000455283.2 ENST00000435976.6 |
