ADHFE1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	10 studies	32% ± 17%	Explore
adipocyte	6 studies	30% ± 8%	Explore
cardiac muscle cell	5 studies	27% ± 6%	Explore
oligodendrocyte precursor cell	4 studies	22% ± 5%	Explore
hepatocyte	3 studies	33% ± 11%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	24% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	1299.77	2561 / 2642	98%	7.05	693 / 705
prostate	100%	2906.62	244 / 245	95%	5.24	479 / 502
liver	100%	4443.90	226 / 226	94%	7.84	382 / 406
thymus	99%	1988.39	648 / 653	92%	2.59	554 / 605
kidney	99%	1595.78	88 / 89	85%	3.07	767 / 901
adrenal gland	95%	1228.58	244 / 258	65%	1.32	150 / 230
breast	98%	1840.96	451 / 459	60%	1.46	667 / 1118
pancreas	99%	1663.94	324 / 328	59%	0.97	105 / 178
ovary	97%	3711.16	175 / 180	58%	1.16	248 / 430
uterus	96%	1823.05	164 / 170	47%	1.16	218 / 459
skin	70%	555.52	1264 / 1809	62%	1.99	293 / 472
lung	90%	1282.79	518 / 578	37%	0.87	430 / 1155
bladder	90%	2435.57	19 / 21	32%	0.80	161 / 504
esophagus	91%	2182.92	1310 / 1445	25%	0.60	45 / 183
stomach	100%	2935.26	358 / 359	7%	0.14	20 / 286
intestine	98%	1750.78	943 / 966	4%	0.07	19 / 527
muscle	100%	3175.73	802 / 803	0%	0	0 / 0
spleen	99%	1437.39	238 / 241	0%	0	0 / 0
blood vessel	99%	2418.07	1316 / 1335	0%	0	0 / 0
adipose	97%	1803.17	1164 / 1204	0%	0	0 / 0
heart	96%	2142.07	823 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	85%	3.09	68 / 80
lymph node	0%	0	0 / 0	45%	0.81	13 / 29
tonsil	0%	0	0 / 0	27%	0.39	12 / 45
peripheral blood	17%	100.16	158 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006103	Biological process	2-oxoglutarate metabolic process
GO_0006539	Biological process	glutamate catabolic process via 2-oxoglutarate
GO_0006629	Biological process	lipid metabolic process
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0047988	Molecular function	hydroxyacid-oxoacid transhydrogenase activity
GO_0004022	Molecular function	alcohol dehydrogenase (NAD+) activity
GO_0046872	Molecular function	metal ion binding

Gene name	ADHFE1
Protein name	Hydroxyacid-oxoacid transhydrogenase, mitochondrial (Alcohol dehydrogenase iron-containing protein 1) Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1) (Fe-containing alcohol dehydrogenase) Alcohol dehydrogenase iron containing 1
Synonyms	HMFT2263
Description	FUNCTION: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. .
Accessions	ENST00000424777.6 [Q8IWW8-3] Q8IWW8 ENST00000443372.5 ENST00000426810.5 ENST00000415254.5 [Q8IWW8-2] ENST00000419955.5 F2Z3E5 ENST00000396621.7 F2Z2N0 B4DV11 ENST00000276576.11 ENST00000396623.8 [Q8IWW8-1] B4DFI7 ENST00000431959.5 ENST00000422166.5 F2Z3D8 ENST00000449512.5

ADHFE1 report