ADH7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001523Biological processretinoid metabolic process
GO_0010430Biological processfatty acid omega-oxidation
GO_0045471Biological processresponse to ethanol
GO_0042573Biological processretinoic acid metabolic process
GO_0042572Biological processretinol metabolic process
GO_0009617Biological processresponse to bacterium
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0048019Molecular functionreceptor antagonist activity
GO_0050153Molecular functionomega-hydroxydecanoate dehydrogenase activity
GO_0004024Molecular functionalcohol dehydrogenase (NAD+) activity, zinc-dependent
GO_0004022Molecular functionalcohol dehydrogenase (NAD+) activity
GO_0004745Molecular functionall-trans-retinol dehydrogenase (NAD+) activity
GO_0019841Molecular functionretinol binding
GO_0004031Molecular functionaldehyde oxidase activity
GO_0035276Molecular functionethanol binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameADH7
Protein nameAll-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase)
Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Synonyms
DescriptionFUNCTION: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives . Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid . In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives . Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal . Catalyzes in the oxidative direction with higher efficiency . Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation . .

AccessionsA0A0C4DG85
E9PFG0
ENST00000482593.5
ENST00000437033.7
ENST00000209665.8 [P40394-1]
C9JP14
P40394
ENST00000476959.5 [P40394-2]
ENST00000474027.1