Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 31% ± 10% | |
| adipocyte | 8 studies | 36% ± 6% | |
| smooth muscle cell | 7 studies | 31% ± 11% | |
| interneuron | 6 studies | 28% ± 11% | |
| GABAergic neuron | 6 studies | 41% ± 19% | |
| glutamatergic neuron | 5 studies | 40% ± 21% | |
| cardiac muscle cell | 5 studies | 52% ± 10% | |
| endothelial cell | 4 studies | 27% ± 11% | |
| pericyte | 4 studies | 29% ± 9% | |
| GABAergic interneuron | 3 studies | 25% ± 8% | |
| neuron | 3 studies | 31% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 96% | 6838.48 | 236 / 245 | 90% | 11.00 | 450 / 502 |
| brain | 82% | 8598.01 | 2174 / 2642 | 92% | 17.50 | 647 / 705 |
| ovary | 94% | 3852.73 | 170 / 180 | 68% | 7.05 | 292 / 430 |
| kidney | 42% | 1571.48 | 37 / 89 | 85% | 21.50 | 770 / 901 |
| uterus | 92% | 4208.18 | 156 / 170 | 30% | 4.16 | 138 / 459 |
| bladder | 95% | 7160.38 | 20 / 21 | 21% | 1.99 | 105 / 504 |
| breast | 66% | 2892.53 | 302 / 459 | 50% | 7.92 | 557 / 1118 |
| esophagus | 75% | 15362.18 | 1089 / 1445 | 36% | 5.24 | 65 / 183 |
| intestine | 82% | 7158.85 | 793 / 966 | 24% | 2.30 | 125 / 527 |
| blood vessel | 100% | 14447.93 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| heart | 96% | 13709.11 | 830 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 13% | 338.56 | 44 / 328 | 74% | 7.85 | 132 / 178 |
| adipose | 84% | 4659.10 | 1017 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 50% | 5615.23 | 180 / 359 | 31% | 4.95 | 90 / 286 |
| lung | 19% | 490.81 | 112 / 578 | 30% | 3.74 | 352 / 1155 |
| spleen | 49% | 1361.66 | 119 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 3% | 84.92 | 9 / 258 | 43% | 4.18 | 100 / 230 |
| liver | 0% | 9.08 | 1 / 226 | 22% | 2.24 | 90 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 20% | 3.05 | 9 / 45 |
| thymus | 4% | 132.28 | 29 / 653 | 10% | 1.32 | 59 / 605 |
| skin | 3% | 89.15 | 56 / 1809 | 9% | 0.53 | 42 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.35 | 2 / 29 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.34 | 4 / 80 |
| muscle | 1% | 29.33 | 8 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006171 | Biological process | cAMP biosynthetic process |
| GO_0007195 | Biological process | adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| GO_0007191 | Biological process | adenylate cyclase-activating dopamine receptor signaling pathway |
| GO_0001973 | Biological process | G protein-coupled adenosine receptor signaling pathway |
| GO_0050885 | Biological process | neuromuscular process controlling balance |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0061178 | Biological process | regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_1904322 | Biological process | cellular response to forskolin |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005929 | Cellular component | cilium |
| GO_0004016 | Molecular function | adenylate cyclase activity |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0008179 | Molecular function | adenylate cyclase binding |
| Gene name | ADCY5 |
| Protein name | Adenylate cyclase 5 Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling . Mediates signaling downstream of ADRB1 . Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion . . |
| Accessions | ENST00000491190.5 A0A8V8TP58 ENST00000699718.1 ENST00000699715.1 ENST00000476455.1 ENST00000462833.6 [O95622-1] ENST00000699714.1 ENST00000470367.2 ENST00000699716.1 F8WBM0 ENST00000483566.2 A0A8V8TNW3 ENST00000309879.9 [O95622-2] B3KWA8 O95622 ENST00000466617.6 C9JRT8 |
