ADAM7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ADAM7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADAM7 at tissue level.

III. Associated gene sets

GO_0003382Biological processepithelial cell morphogenesis
GO_1905867Biological processepididymis development
GO_1902093Biological processpositive regulation of flagellated sperm motility
GO_0006508Biological processproteolysis
GO_1902492Biological processpositive regulation of sperm capacitation
GO_0005886Cellular componentplasma membrane
GO_0004222Molecular functionmetalloendopeptidase activity

IV. Literature review

[source]
Gene nameADAM7
Protein nameADAM metallopeptidase domain 7
ADAM7 protein
Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83)
SynonymsGP83
DescriptionFUNCTION: Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (By similarity). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (By similarity). This is a non catalytic metalloprotease-like protein (By similarity). .

AccessionsQ86XK9
ENST00000380789.5
E5RK87
ENST00000441335.6 [Q9H2U9-2]
ENST00000520720.1
Q9H2U9
C9JK28
ENST00000175238.10 [Q9H2U9-1]