ADAM2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ADAM2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADAM2 at tissue level.

III. Associated gene sets

GO_0008584Biological processmale gonad development
GO_0007339Biological processbinding of sperm to zona pellucida
GO_0010628Biological processpositive regulation of gene expression
GO_0007155Biological processcell adhesion
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0006508Biological processproteolysis
GO_0008542Biological processvisual learning
GO_0030534Biological processadult behavior
GO_0009986Cellular componentcell surface
GO_0032991Cellular componentprotein-containing complex
GO_0005886Cellular componentplasma membrane
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameADAM2
Protein nameDisintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta)
Disintegrin and metalloproteinase domain-containing protein 2 (Fertilin subunit beta) (PH-30) (PH30-beta)
SynonymsFTNB
hCG_38684
DescriptionFUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. .

FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. .

AccessionsENST00000613160.4 [Q99965-2]
ENST00000347580.8 [Q99965-2]
Q6P2G0
ENST00000265708.9 [Q99965-1]
ENST00000521880.5
ENST00000633755.1
Q99965
ENST00000379853.6
B4DWY7
ENST00000619491.2
ENST00000620181.4 [Q99965-1]
ENST00000611998.3